In WP1 the main activities are the selection of the microorganisms to be investigated, their cultivation and the formulation of the initial extracts library. More specifically, 40.000 known microbial metabolites from the dictionary of microbial natural products ANTIBASE will be screened in silico against selected biological targets with cosmeceutical interest. Based on the virtual predictions, species containing hit scaffolds will be prioritized according to several criteria including cultivability of microorganism, known toxicity of compounds etc. Based on this list, ~100 microorganisms will be selected for investigation from the existing fully characterized culture collection of the partners. Continuously, all selected strains will be cultured using nutritional arrays (~10 different conditions). The produced biomass will be extracted to give ~1000 primary extracts that will form a 2D barcoded extracts library which will be forwarded to WP2 for biological evaluation.